Michal Geva Selected Research

pridopidine

5/2022	Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.
11/2021	Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma.
1/2021	The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models.
1/2021	Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study.
1/2020	Additional Safety and Exploratory Efficacy Data at 48 and 60 Months from Open-HART, an Open-Label Extension Study of Pridopidine in Huntington Disease.
1/2019	Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.
1/2019	Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model.
1/2019	Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.
1/2019	Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.
12/2017	Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.

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Michal Geva Research Topics

Disease

14	Huntington Disease (Huntington's Disease) 05/2022 - 01/2016
7	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2021 - 10/2013
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/2022 - 01/2021
2	Parkinson Disease (Parkinson's Disease) 01/2019 - 01/2019
2	Parkinsonian Disorders (Parkinsonism) 01/2019 - 01/2019
2	Demyelinating Diseases (Demyelinating Disease) 01/2012 - 08/2010
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 05/2022
1	Glaucoma 11/2021
1	Retinal Degeneration 11/2021
1	Optic Nerve Diseases (Optic Neuropathy) 11/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Dyskinesias (Dyskinesia) 01/2019
1	Alzheimer Disease (Alzheimer's Disease) 01/2019
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 11/2013
1	Chronic Wasting Disease 10/2013
1	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 10/2013
1	Scrapie 10/2013
1	Brain Diseases (Brain Disorder) 01/2012
1	Leukoencephalopathies 01/2012
1	Gliosis 01/2012

Drug/Important Bio-Agent (IBA)

12	pridopidineIBA 05/2022 - 01/2016
7	Sigma-1 ReceptorIBA 11/2021 - 01/2017
2	Neuroprotective AgentsIBA 11/2021 - 01/2016
2	Huntingtin ProteinIBA 01/2019 - 01/2018
2	CuprizoneIBA 01/2012 - 08/2010
1	Opioid Analgesics (Opioids)IBA 05/2022
1	Glutathione (Reduced Glutathione)IBA 05/2022
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 05/2022
1	Membrane Proteins (Integral Membrane Proteins)IBA 05/2022
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 05/2022
1	Proteins (Proteins, Gene)FDA Link 05/2022
1	RNA (Ribonucleic Acid)IBA 05/2022
1	Transcription Factors (Transcription Factor)IBA 05/2022
1	Citric Acid (Citrate)FDA LinkGeneric 05/2022
1	Lysosomal Membrane ProteinsIBA 05/2022
1	CholesterolIBA 04/2021
1	Dopamine (Intropin)FDA LinkGeneric 01/2021
1	fallyprideIBA 01/2021
1	1'- benzyl- 3- (2- fluoroethyl)- 3H- spiro((2)benzofuran- 1,4'- piperidine)IBA 01/2021
1	Investigational DrugsIBA 01/2021
1	Levodopa (L Dopa)FDA LinkGeneric 01/2019
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2019
1	polyglutamineIBA 01/2019
1	Oxidopamine (6 Hydroxydopamine)IBA 01/2019
1	NucleotidesIBA 01/2017
1	HydrazonesIBA 11/2013
1	AmidesIBA 11/2013
1	Pharmaceutical PreparationsIBA 10/2013
1	PrionsIBA 10/2013
1	Eukaryotic Initiation Factor-2B (Eukaryotic Initiation Factor 2B)IBA 01/2012
1	LipopolysaccharidesIBA 01/2012
1	Peptide Initiation Factors (Initiation Factor)IBA 01/2012

Therapy/Procedure

1	Therapeutics 11/2013
1	Injections 01/2012